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Research Groups

Logo for Sheila Singh Lab

Singh Lab

Dr. Singh's lab focuses on stem cell based investigations of brain cancer including single cell sequencing, measures of spatial heterogeneity, and multi-omics characterizations for novel therapy development. The three main programs focus on:

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  • Medulloblastoma

  • Glioblastoma

  • Brain Metastases

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More here.

Logo for CRANI Research Group

CRANI Research Group

Led by Dr. Sharma, The Collaborative Research Program in Neurosurgery and Intensive Care utilizes methodology to work with interdisciplinary experts to identify and answer clinical questions bridging these intimately related fields.
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Key Areas of Interest:
  • Neurotrauma
  • Neurocritical Care
  • Neuro-oncology
  • Randomized Trials
  • Meta-Analyses

CIP

Clinician Investigator Program

The competitive Ministry of Health funded McMaster Clinician Investigator Program is frequently secured by neurosurgical residents during dedicated research time. This program results in RCPSC certification on completion.
More here.
Logo for Pediatric Brain Tumor Study Group

Pediatric Brain Tumor Study Group

Under the leadership of Dr. Singh and Dr. Fleming, the Paediatric Brain Tumour Study Group is a multi-disciplinary research network of students and faculty members replete with potential for clinical questioning.
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Key Areas of Interest:
  • Operative Outcomes and Complications
  • Clinical Neuropsychology
  • Clinical Neurophysiology and Neuroanatomy
  • Long-term Sequelae and Quality of Life
 
More here. 

Select Publications

An HLA-G/SPAG9/STAT3 axis promotes brain metastases.

Bassey-Archibong BI, Rajendra Chokshi C, Aghaei N, Kieliszek AM, Tatari N, McKenna D, Singh M, Kalpana Subapanditha M, Parmar A, Mobilio D, Savage N, Lam F, Tokar T, Provias J, Lu Y, Chafe SC, Swanton C, Hynds RE, Venugopal C, Singh SK.

Proc Natl Acad Sci U S A. 2023 Feb 21;120(8):e2205247120. doi: 10.1073/pnas.2205247120. Epub 2023 Feb 13.

PMID: 36780531

Systematic Review and Meta-Analysis of Randomized Controlled Trials for Scalp Block in Craniotomy.

Duda T, Lannon M, Gandhi P, Martyniuk A, Farrokhyar F, Sharma S.

Neurosurgery. 2023 Feb 10. doi: 10.1227/neu.0000000000002381. Online ahead of print.

PMID: 36762905

Rurality index score and pediatric neuro-oncological outcome in Ontario.

Kameda-Smith MM, Pond GR, Seow H.

J Neurosurg Pediatr. 2023 Jan 13:1-7. doi: 10.3171/2022.12.PEDS22446. Online ahead of print.

PMID: 36640100

External ventricular drainage in the management of pediatric patients with posterior fossa tumors and hydrocephalus: a retrospective cohort study.

Verhey LH, Maharaj A, Patel N, Manoranjan B, Ajani O, Fleming A, Farrokhyar F, Singh SK, Yarascavitch B; on behalf the Pediatric Brain Tumor Study Group.

Childs Nerv Syst. 2023 Jan 12. doi: 10.1007/s00381-022-05818-8. Online ahead of print.

PMID: 36633680

Author Correction: Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma.

Kameda-Smith MM, Zhu H, Luo EC, Suk Y, Xella A, Yee B, Chokshi C, Xing S, Tan F, Fox RG, Adile AA, Bakhshinyan D, Brown K, Gwynne WD, Subapanditha M, Miletic P, Picard D, Burns I, Moffat J, Paruch K, Fleming A, Hope K, Provias JP, Remke M, Lu Y, Reya T, Venugopal C, Reimand J, Wechsler-Reya RJ, Yeo GW, Singh SK.

Nat Commun. 2023 Jan 10;14(1):136. doi: 10.1038/s41467-023-35816-6.

PMID: 36627300 Free PMC article. No abstract available.

Management of deep surgical site infections of the spine: a Canadian nationwide survey.

Sarraj M, Alqahtani A, Thornley P, Koziarz F, Bailey CS, Freire-Archer M, Bhanot K, Kachur E, Bhandari M, Oitment C.

J Spine Surg. 2022 Dec;8(4):443-452. doi: 10.21037/jss-22-47.

PMID: 36606001 Free PMC article.

Diagnosis and management of intraparenchymal rhabdomyosarcoma.

Lannon M, Al-Sajee D, Bourgeois J, Sehl J, Reddy K, Lu JQ.

Br J Neurosurg. 2023 Jan 4:1-8. doi: 10.1080/02688697.2022.2163980. Online ahead of print.

PMID: 36597892

Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma.

Kameda-Smith MM, Zhu H, Luo EC, Suk Y, Xella A, Yee B, Chokshi C, Xing S, Tan F, Fox RG, Adile AA, Bakhshinyan D, Brown K, Gwynne WD, Subapanditha M, Miletic P, Picard D, Burns I, Moffat J, Paruch K, Fleming A, Hope K, Provias JP, Remke M, Lu Y, Reya T, Venugopal C, Reimand J, Wechsler-Reya RJ, Yeo GW, Singh SK.

Nat Commun. 2022 Dec 6;13(1):7506. doi: 10.1038/s41467-022-35118-3.

PMID: 36473869 Free PMC article.

Computed Tomography Angiography Compared with Computed Tomography Perfusion in the Diagnosis of Cerebral Vasospasm: A Systematic Review and Meta-Analysis.

Bergin B, Ragulojan M, Trivedi A, Kesserwan M, Farrokhyar F, Sharma S.

World Neurosurg. 2023 Feb;170:e340-e350. doi: 10.1016/j.wneu.2022.11.016. Epub 2022 Nov 8.

PMID: 36368456

Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma.

Gwynne WD, Suk Y, Custers S, Mikolajewicz N, Chan JK, Zador Z, Chafe SC, Zhai K, Escudero L, Zhang C, Zaslaver O, Chokshi C, Shaikh MV, Bakhshinyan D, Burns I, Chaudhry I, Nachmani O, Mobilio D, Maich WT, Mero P, Brown KR, Quaile AT, Venugopal C, Moffat J, Montenegro-Burke JR, Singh SK.

Cancer Cell. 2022 Dec 12;40(12):1488-1502.e7. doi: 10.1016/j.ccell.2022.10.009. Epub 2022 Nov 10.

PMID: 36368321

A Canadian National Survey of the Neurosurgical Management of Intracranial Abscesses.

Kameda-Smith MM, Ragulojan M, Hart S, Duda TR, MacLean MA, Chainey J, Aminnejad M, Rizzuto M, Bergeron D, Eagles M, Chalil A, Langlois AM, Gariepy C, Persad A, Hasen M, Wang A, Elkaim L, Christie S, Farrokhyar F, Reddy K; Canadian Neurosurgery Research Collaborative.

Can J Neurol Sci. 2022 Oct 3:1-8. doi: 10.1017/cjn.2022.299. Online ahead of print.

PMID: 36184886

The proteomic landscape of glioblastoma recurrence reveals novel and targetable immunoregulatory drivers.

Tatari N, Khan S, Livingstone J, Zhai K, Mckenna D, Ignatchenko V, Chokshi C, Gwynne WD, Singh M, Revill S, Mikolajewicz N, Zhu C, Chan J, Hawkins C, Lu JQ, Provias JP, Ask K, Morrissy S, Brown S, Weiss T, Weller M, Han H, Greenspoon JN, Moffat J, Venugopal C, Boutros PC, Singh SK, Kislinger T.

Acta Neuropathol. 2022 Dec;144(6):1127-1142. doi: 10.1007/s00401-022-02506-4. Epub 2022 Sep 30.

PMID: 36178522

Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma.

Qazi MA, Salim SK, Brown KR, Mikolajewicz N, Savage N, Han H, Subapanditha MK, Bakhshinyan D, Nixon A, Vora P, Desmond K, Chokshi C, Singh M, Khoo A, Macklin A, Khan S, Tatari N, Winegarden N, Richards L, Pugh T, Bock N, Mansouri A, Venugopal C, Kislinger T, Goyal S, Moffat J, Singh SK.

Cell Rep. 2022 Sep 27;40(13):111420. doi: 10.1016/j.celrep.2022.111420.

PMID: 36170831

Intravenous milrinone for delayed cerebral ischaemia in aneurysmal subarachnoid haemorrhage: a systematic review.

Lannon M, Martyniuk A, Sharma S.

Br J Neurosurg. 2022 Sep 26:1-6. doi: 10.1080/02688697.2022.2125160. Online ahead of print.

PMID: 36154769

Randomized controlled trials in neurosurgery.

Takroni R, Sharma S, Reddy K, Zagzoog N, Aljoghaiman M, Alotaibi M, Farrokhyar F.

Surg Neurol Int. 2022 Aug 26;13:379. doi: 10.25259/SNI_1032_2021. eCollection 2022.

PMID: 36128088 Free PMC article. Review.

Long-Term Survivorship of Cervical Spine Procedures; A Survivorship Meta-Analysis and Meta-Regression.

Sarraj M, Hache P, Foroutan F, Oitment C, Marion TE, Guha D, Pahuta M.

Global Spine J. 2022 Sep 7:21925682221125766. doi: 10.1177/21925682221125766. Online ahead of print.

PMID: 36069054

Surgical aspiration versus excision for intraparenchymal abscess: a systematic review and Meta-analysis.

Lannon M, Trivedi A, Martyniuk A, Farrokhyar F, Sharma S.

Br J Neurosurg. 2022 Dec;36(6):743-749. doi: 10.1080/02688697.2022.2118231. Epub 2022 Sep 4.

PMID: 36062586

Derivation and culturing of neural stem cells from human embryonic brain tissue.

Suk Y, Kieliszek A, Mobilio D, Venugopal C, Singh SK.

STAR Protoc. 2022 Aug 18;3(3):101628. doi: 10.1016/j.xpro.2022.101628. eCollection 2022 Sep 16.

PMID: 36035806 Free PMC article.

Work-up and Management of Asymptomatic Extracranial Traumatic Vertebral Artery Injury.

Maclean MA, Touchette CJ, Duda T, Almojuela A, Bergeron D, Kameda-Smith M, Persad ARL, Sader N, Alant J, Christie SD.

Can J Neurol Sci. 2022 Aug 26:1-11. doi: 10.1017/cjn.2022.292. Online ahead of print.

PMID: 36017734

Reoperation in adult patients with recurrent glioblastoma: A matched cohort analysis.

Yang K, Ellenbogen Y, Martyniuk A, Sourour M, Takroni R, Somji M, Gardiner E, Hui K, Odedra D, Larrazabal R, Algird A, Kachur E, Reddy K, Murty N, Farrokhyar F, Singh SK.

Neurooncol Adv. 2022 Jul 13;4(1):vdac115. doi: 10.1093/noajnl/vdac115. eCollection 2022 Jan-Dec.

PMID: 35990706 Free PMC article.

Dual Antigen T Cell Engagers Targeting CA9 as an Effective Immunotherapeutic Modality for Targeting CA9 in Solid Tumors.

Tatari N, Zhang X, Chafe SC, McKenna D, Lawson KA, Subapanditha M, Shaikh MV, Seyfrid M, Savage N, Venugopal C, Moffat J, Singh SK.

Front Immunol. 2022 Jul 6;13:905768. doi: 10.3389/fimmu.2022.905768. eCollection 2022.

PMID: 35874663 Free PMC article.

Retrospective Review of the Clinical Outcomes of Surgically Managed Patients with Intracranial Abscesses: A Single-Center Review.

Kameda-Smith MM, Duda T, Duncan DB, Ragulojan M, Jung Y, Farrokhyar F, Main C, Reddy K.

World Neurosurg. 2022 Sep;165:e697-e711. doi: 10.1016/j.wneu.2022.06.126. Epub 2022 Jul 5.

PMID: 35798293

A primary DICER1-sarcoma with KRAS and TP53 mutations in a child with suspected ECCL.

Yang K, Wang J, Kanwar N, Villani A, Ajani O, Fleming A, Patil V, Mamatjan Y, Wei Q, Malkin D, Shlien A, Zadeh G, Provias J.

Brain Tumor Pathol. 2022 Oct;39(4):225-231. doi: 10.1007/s10014-022-00437-2. Epub 2022 Jun 6.

PMID: 35668302

Subarachnoid Hemorrhage, Delayed Cerebral Ischemia, and Milrinone Use in Canada.

Eagles ME, MacLean MA, Kameda-Smith MM, Duda T, Persad ARL, Almojuela A, Bokhari R, Iorio-Morin C, Elkaim LM, Rizzuto MA, Lownie SP, Christie SD, Teitelbaum J; Canadian Neurosurgery Research Collaborative.

Can J Neurol Sci. 2022 Apr 28:1-9. doi: 10.1017/cjn.2022.44. Online ahead of print.

PMID: 35477442

The Role of a Longitudinal, Multidisciplinary Clinic in Building a Unique Research Collaborative.

Gonzales AA, Mastrolonardo A, Winget K, Ragulojan M, Fleming AJ, Singh SK.

Front Oncol. 2022 Apr 8;12:857699. doi: 10.3389/fonc.2022.857699. eCollection 2022.

PMID: 35463317 Free PMC article.

Spinal calcifying pseudoneoplasm of the neuraxis (CAPNON) and CAPNON-like lesions: CAPNON overlapping with calcified synovial cysts.

Lu JQ, Al Mohammadi WJB, Fong C, Yang K, Moodley J, Provias J, Popovic S, Chebib I, Cenic A.

Pathology. 2022 Aug;54(5):573-579. doi: 10.1016/j.pathol.2022.01.003. Epub 2022 Apr 11.

PMID: 35422321

The Road to CAR T-Cell Therapies for Pediatric CNS Tumors: Obstacles and New Avenues.

Burns I, Gwynne WD, Suk Y, Custers S, Chaudhry I, Venugopal C, Singh SK.

Front Oncol. 2022 Jan 27;12:815726. doi: 10.3389/fonc.2022.815726. eCollection 2022.

PMID: 35155252 Free PMC article.

Computed Tomography Hounsfield Units as a Predictor of Reoperation and Graft Subsidence After Standalone and Multilevel Lateral Lumbar Interbody Fusion.

Guha D, Mushlin HM, Muthiah N, Vodovotz LL, Agarwal N, Alan N, Hamilton DK, Okonkwo DO, Kanter AS.

World Neurosurg. 2022 May;161:e417-e426. doi: 10.1016/j.wneu.2022.02.015. Epub 2022 Feb 8.

PMID: 35149250

Comprehensive comparison of carotid endarterectomy primary closure and patch angioplasty: A single-institution experience.

Zagzoog N, Elgheriani A, Attar A, Takroni R, Aljoghaiman M, Klotz L, Vandervelde C, Darling C, Farrokhyar F, Martyniuk A, Algird A.

Surg Neurol Int. 2022 Jan 5;13:1. doi: 10.25259/SNI_1013_2021. eCollection 2022.

PMID: 35127201 Free PMC article.

Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma.

Nawar N, Bukhari S, Adile AA, Suk Y, Manaswiyoungkul P, Toutah K, Olaoye OO, Raouf YS, Sedighi A, Garcha HK, Hassan MM, Gwynne W, Israelian J, Radu TB, Geletu M, Abdeldayem A, Gawel JM, Cabral AD, Venugopal C, de Araujo ED, Singh SK, Gunning PT.

J Med Chem. 2022 Feb 24;65(4):3193-3217. doi: 10.1021/acs.jmedchem.1c01585. Epub 2022 Feb 4.

PMID: 35119267

Postoperative CT scans after resection of brain metastases: neurosurgical routine or added value?

Yang K, Landry AP, Aljoghaiman M, Gutierrez E, Millesi M, Leite M, Kalyvas A, Jablonska PA, Vialet J, Weiss J, Millar BA, Conrad T, Laperriere N, Bernstein M, Zadeh G, Shultz D, Kongkham PN.

J Neurooncol. 2022 Mar;157(1):157-163. doi: 10.1007/s11060-022-03957-1. Epub 2022 Jan 29.

PMID: 35092549

Brain Toxoplasmosis and Bacterial Infection after Liver Transplantation.

Graham AK, Sharma S, Yamamura D, Kameda-Smith MM, Main C, Lu JQ.

Can J Neurol Sci. 2023 Jan;50(1):155-157. doi: 10.1017/cjn.2021.494. Epub 2021 Nov 19.

PMID: 35067253 No abstract available.

Intracranial hemorrhage after head injury among older patients on anticoagulation seen in the emergency department: a population-based cohort study.

Grewal K, Atzema CL, Austin PC, de Wit K, Sharma S, Mittmann N, Borgundvaag B, McLeod SL.

CMAJ. 2021 Oct 12;193(40):E1561-E1567. doi: 10.1503/cmaj.210811.

PMID: 35040805 Free PMC article.

Image-Guided versus Freehand Ventricular Drain Insertion: Systematic Review and Meta-analysis.

Aljoghaiman M, Bergen B, Takroni R, Wang B, Eangles P, Farrokhyar F, Sharma S.

World Neurosurg. 2022 Apr;160:85-93.e5. doi: 10.1016/j.wneu.2022.01.036. Epub 2022 Jan 13.

PMID: 35033689 Review.

CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment.

Seyfrid M, Maich WT, Shaikh VM, Tatari N, Upreti D, Piyasena D, Subapanditha M, Savage N, McKenna D, Mikolajewicz N, Han H, Chokshi C, Kuhlmann L, Khoo A, Salim SK, Archibong-Bassey B, Gwynne W, Brown K, Murtaza N, Bakhshinyan D, Vora P, Venugopal C, Moffat J, Kislinger T, Singh S.

J Immunother Cancer. 2022 Jan;10(1):e003289. doi: 10.1136/jitc-2021-003289.

PMID: 35017149 Free PMC article.

Childhood Medulloblastoma: An Overview.

Suk Y, Gwynne WD, Burns I, Venugopal C, Singh SK.

Methods Mol Biol. 2022;2423:1-12. doi: 10.1007/978-1-0716-1952-0_1.

PMID: 34978683 Review.

Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence.

Bakhshinyan D, Adile AA, Liu J, Gwynne WD, Suk Y, Custers S, Burns I, Singh M, McFarlane N, Subapanditha MK, Qazi MA, Vora P, Kameda-Smith MM, Savage N, Desmond KL, Tatari N, Tran D, Seyfrid M, Hope K, Bock NA, Venugopal C, Bader GD, Singh SK.

Sci Adv. 2021 Dec 10;7(50):eabi5568. doi: 10.1126/sciadv.abi5568. Epub 2021 Dec 8.

PMID: 34878832 Free PMC article.

Low and steady wins the race: For melanoma brain metastases, is prevention better than a cure?

Kieliszek AM, Aghaei N, Bassey-Archibong BI, Singh SK.

Neuro Oncol. 2022 Feb 1;24(2):226-228. doi: 10.1093/neuonc/noab267.

PMID: 34850156 Free PMC article. No abstract available.

A nationwide prospective multicenter study of external ventricular drainage: accuracy, safety, and related complications.

Dakson A, Kameda-Smith M, Staudt MD, Lavergne P, Makarenko S, Eagles ME, Ghayur H, Guo RC, Althagafi A, Chainey J, Touchette CJ, Elliott C, Iorio-Morin C, Tso MK, Greene R, Bargone L, Christie SD.

J Neurosurg. 2021 Nov 26:1-9. doi: 10.3171/2021.7.JNS21421. Online ahead of print.

PMID: 34826821

Comparison of Two Drainage Systems on Chronic Subdural Hematoma Recurrence.

Takroni R, Zagzoog N, Patel N, Martyniuk A, Singh S, Farrokhyar F, Trivedi A, Alotaibi M, Algird A.

J Neurol Surg A Cent Eur Neurosurg. 2021 Nov 16. doi: 10.1055/a-1698-6212. Online ahead of print.

PMID: 34784622

Identification of five important genes to predict glioblastoma subtypes.

Tang Y, Qazi MA, Brown KR, Mikolajewicz N, Moffat J, Singh SK, McNicholas PD.

Neurooncol Adv. 2021 Oct 10;3(1):vdab144. doi: 10.1093/noajnl/vdab144. eCollection 2021 Jan-Dec.

PMID: 34765972 Free PMC article.

In vitro evaluation of CAR-T cells in patient-derived glioblastoma models.

Brakel BA, Chokshi CR, Salim SK, Venugopal C, Singh S.

STAR Protoc. 2021 Oct 29;2(4):100920. doi: 10.1016/j.xpro.2021.100920. eCollection 2021 Dec 17.

PMID: 34761232 Free PMC article.

Craniocerebral gunshot injury bullet migration to the cardiac right ventricle.

Duda T, Zhang E, Reddy K.

Surg Neurol Int. 2021 Sep 30;12:491. doi: 10.25259/SNI_221_2021. eCollection 2021.

PMID: 34754541 Free PMC article.

Seizures following cervical laminectomy and lateral mass fusion: case report and review of the literature.

Al-Gethami H, Cenic A, Kachur E.

J Spine Surg. 2021 Sep;7(3):445-455. doi: 10.21037/jss-20-642.

PMID: 34734149 Free PMC article.

Degenerative Cervical Myelopathy: Clinical Presentation, Assessment, and Natural History.

Lannon M, Kachur E.

J Clin Med. 2021 Aug 17;10(16):3626. doi: 10.3390/jcm10163626.

PMID: 34441921 Free PMC article. Review.

Pediatric craniocerebral gunshot injuries: A National Trauma Database study.

Lannon MM, Duda T, Martyniuk A, Engels PT, Sharma SV.

J Trauma Acute Care Surg. 2022 Feb 1;92(2):428-435. doi: 10.1097/TA.0000000000003385.

PMID: 34407004

Advances in Immunotherapy for Adult Glioblastoma.

Chokshi CR, Brakel BA, Tatari N, Savage N, Salim SK, Venugopal C, Singh SK.

Cancers (Basel). 2021 Jul 7;13(14):3400. doi: 10.3390/cancers13143400.

PMID: 34298615 Free PMC article. Review.

Which older emergency patients are at risk of intracranial bleeding after a fall? A protocol to derive a clinical decision rule for the emergency department.

de Wit K, Mercuri M, Clayton N, Worster A, Mercier E, Emond M, Varner C, McLeod SL, Eagles D, Stiell I, Barbic D, Morris J, Jeanmonod R, Kagoma Y, Shoamanesh A, Engels PT, Sharma S, Kearon C, Papaioannou A, Parpia S; Network of Canadian Emergency Researchers.

BMJ Open. 2021 Jul 2;11(7):e044800. doi: 10.1136/bmjopen-2020-044800.

PMID: 34215600 Free PMC article.

Third Nerve Palsy Due to Intracranial Aneurysms and Recovery after Endovascular Coiling.

Kameda-Smith M, Pai A, Jung Y, Khan D, Adile AA, Hui K, Martyniuk A, Larrazabal R, Algird A, Klurfan P, Gunnarsson T, Farrokhyar F, van Adel B.

Can J Neurol Sci. 2022 Jul;49(4):560-568. doi: 10.1017/cjn.2021.145. Epub 2021 Jun 24.

PMID: 34167603

Hydrocéphalie asymptomatique.

Persad AR, Bass V, Meguro K.

CMAJ. 2021 Jun 21;193(25):E994-E995. doi: 10.1503/cmaj.200889-f.

PMID: 34155057 Free PMC article. French. No abstract available.

The Association between Prolonged Antibiotic Use in Culture Negative Infants and Length of Hospital Stay and Total Hospital Costs.

Sourour W, Sanchez V, Sourour M, Burdine J, Lien ER, Nguyen D, Jain SK.

Am J Perinatol. 2021 May 11. doi: 10.1055/s-0041-1729560. Online ahead of print.

PMID: 33975363

A single center experience in the management of progressive juvenile pilocytic astrocytoma.

Shams I, Manoranjan B, Voth R, Ragulojan M, Ajani O, Yarascavitch B, Singh SK, Fleming AJ.

J Neurosurg Sci. 2021 Apr 16. doi: 10.23736/S0390-5616.21.05169-9. Online ahead of print.

PMID: 33870664

Asymptomatic hydrocephalus.

Persad AR, Bass V, Meguro K.

CMAJ. 2021 Apr 6;193(14):E480. doi: 10.1503/cmaj.200889.

PMID: 33824146 Free PMC article. No abstract available.

Cost-Effective Cranioplasty Utilizing 3D Printed Molds: A Canadian Single-Center Experience.

Lannon M, Algird A, Alsunbul W, Wang BH.

Can J Neurol Sci. 2022 Mar;49(2):196-202. doi: 10.1017/cjn.2021.57. Epub 2021 Apr 5.

PMID: 33818332

Cross-sectional analysis of women in neurosurgery: a Canadian perspective.

Veilleux C, Samuel N, Yan H, Bass V, Al-Shahrani R, Mansur A, Rutka JT, Zadeh G, Hodaie M, Milot G.

Neurosurg Focus. 2021 Mar;50(3):E13. doi: 10.3171/2020.12.FOCUS20959.

PMID: 33789236

A systematic review of the efficacy of surgical intervention in the management of symptomatic Tarlov cysts: a meta-analysis.

Kameda-Smith MM, Fathalla Z, Ibrahim N, Astaneh B, Farrokhyar F.

Br J Neurosurg. 2021 Mar 23:1-12. doi: 10.1080/02688697.2021.1874294. Online ahead of print.

PMID: 33754918

Does UV Light as an Adjunct to Conventional Treatment Improve Healing and Reduce Infection in Wounds? A Systematic Review.

Inkaran J, Tenn A, Martyniuk A, Farrokhyar F, Cenic A.

Adv Skin Wound Care. 2021 Apr 1;34(4):1-6. doi: 10.1097/01.ASW.0000734384.52295.92.

PMID: 33739951

In Reply to the Letter to the Editor Regarding "Determining the Diagnostic Utility of Lumbar Punctures in CT Negative Suspected Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis".

Kameda-Smith M, Farrokhyar F.

World Neurosurg. 2021 Mar;147:249. doi: 10.1016/j.wneu.2020.12.151.

PMID: 33685022 No abstract available.

Pharmacoprophylaxis for Venous Thromboembolism in Spinal Surgery: A Systematic Review and Meta-analysis.

Ellenbogen Y, Power RG, Martyniuk A, Engels PT, Sharma SV, Kasper EM.

World Neurosurg. 2021 Jun;150:e144-e154. doi: 10.1016/j.wneu.2021.02.120. Epub 2021 Mar 6.

PMID: 33684581

ETS-Domain Transcription Factor Elk-1 Regulates Stemness Genes in Brain Tumors and CD133+ BrainTumor-Initiating Cells.

Sogut MS, Venugopal C, Kandemir B, Dag U, Mahendram S, Singh S, Gulfidan G, Arga KY, Yilmaz B, Kurnaz IA.

J Pers Med. 2021 Feb 14;11(2):125. doi: 10.3390/jpm11020125.

PMID: 33672811 Free PMC article.

Frame-based versus frameless stereotactic brain biopsies: A systematic review and meta-analysis.

Kesserwan MA, Shakil H, Lannon M, McGinn R, Banfield L, Nath S, Alotaibi M, Kasper E, Sharma S.

Surg Neurol Int. 2021 Feb 10;12:52. doi: 10.25259/SNI_824_2020. eCollection 2021.

PMID: 33654555 Free PMC article.

Safety of Early Mobilization in Patients With Intraoperative Cerebrospinal Fluid Leak in Minimally Invasive Spine Surgery: A Case Series.

Aljoghaiman M, Ellenbogen Y, Takroni R, Yang K, Farrokhyar F, Reddy K.

Oper Neurosurg (Hagerstown). 2021 Jun 15;21(1):1-5. doi: 10.1093/ons/opab041.

PMID: 33609122

Calcifying Pseudoneoplasm of the Neuraxis: From Pathogenesis to Diagnostic and Therapeutic Considerations.

Yang K, Reddy K, Chebib I, Hammond R, Lu JQ.

World Neurosurg. 2021 Apr;148:165-176. doi: 10.1016/j.wneu.2021.01.076. Epub 2021 Jan 26.

PMID: 33508489 Review.

The Strange Case of Jekyll and Hyde: Parallels Between Neural Stem Cells and Glioblastoma-Initiating Cells.

Bakhshinyan D, Savage N, Salim SK, Venugopal C, Singh SK.

Front Oncol. 2021 Jan 8;10:603738. doi: 10.3389/fonc.2020.603738. eCollection 2020.

PMID: 33489908 Free PMC article. Review.

Case Report: Endovascular Treatment of a Giant Distal PICA Aneurysm in Association With a Cerebellar AVM: A Report on Treatment Considerations and a Literature Review.

Khayat HA, Hawkes CM, Algird AR.

Front Neurol. 2020 Dec 18;11:611377. doi: 10.3389/fneur.2020.611377. eCollection 2020.

PMID: 33391170 Free PMC article.

A Patient-Derived Xenograft Model of Glioblastoma.

Chokshi CR, Savage N, Venugopal C, Singh SK.

STAR Protoc. 2020 Nov 21;1(3):100179. doi: 10.1016/j.xpro.2020.100179. eCollection 2020 Dec 18.

PMID: 33377073 Free PMC article.

Preclinical Testing of CAR T Cells in a Patient-Derived Xenograft Model of Glioblastoma.

Tatari N, Maich WT, Salim SK, Mckenna D, Venugopal C, Singh S.

STAR Protoc. 2020 Dec 2;1(3):100174. doi: 10.1016/j.xpro.2020.100174. eCollection 2020 Dec 18.

PMID: 33377068 Free PMC article.

Assessing the Safety of a Cell-Based Immunotherapy for Brain Cancers Using a Humanized Model of Hematopoiesis.

Salim SK, Xu J, Wong N, Venugopal C, Hope KJ, Singh SK.

STAR Protoc. 2020 Oct 7;1(3):100124. doi: 10.1016/j.xpro.2020.100124. eCollection 2020 Dec 18.

PMID: 33377018 Free PMC article.

Multiple pathological components in gliosarcoma.

Jiang NN, Larrazabal R, Alsunbul W, Lu JQ.

J Biomed Res. 2020 Sep 25;35(5):408-410. doi: 10.7555/JBR.34.20200089.

PMID: 33342772 Free PMC article. No abstract available.

Determining the Diagnostic Utility of Lumbar Punctures in Computed Tomography Negative Suspected Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis.

Kameda-Smith M, Aref M, Jung Y, Ghayur H, Farrokhyar F.

World Neurosurg. 2021 Apr;148:e27-e34. doi: 10.1016/j.wneu.2020.11.152. Epub 2020 Dec 4.

PMID: 33285333

Strategies to Enhance the Efficacy of T-Cell Therapy for Central Nervous System Tumors.

Upreti D, Bakhshinyan D, Bloemberg D, Vora P, Venugopal C, Singh SK.

Front Immunol. 2020 Nov 12;11:599253. doi: 10.3389/fimmu.2020.599253. eCollection 2020.

PMID: 33281826 Free PMC article. Review.

ALK-negative CNS anaplastic large cell lymphoma: case report and review of literature.

Lannon M, Lu JQ, Chum M, Wang BH.

Br J Neurosurg. 2020 Nov 30:1-6. doi: 10.1080/02688697.2020.1839630. Online ahead of print.

PMID: 33253051

WNT: an unexpected tumor suppressor in medulloblastoma.

Manoranjan B, Adile AA, Venugopal C, Singh SK.

Mol Cell Oncol. 2020 Oct 25;7(6):1834903. doi: 10.1080/23723556.2020.1834903. eCollection 2020.

PMID: 33241114 Free PMC article.

A Review of the Neurosurgical Management of Brain Metastases During Pregnancy.

Proskynitopoulos PJ, Lam FC, Sharma S, Young BC, Laviv Y, Kasper EM.

Can J Neurol Sci. 2021 Sep;48(5):698-707. doi: 10.1017/cjn.2020.254. Epub 2020 Nov 20.

PMID: 33213549 Free PMC article.

Hemorrhagic Complications of Invasive Intracranial Pressure Monitor Placement in Acute Liver Failure: Outcomes of a Single-Center Protocol and Comprehensive Literature Review.

Jinadasa SP, Ruan QZ, Bayoumi AB, Sharma SV, Boone MD, Malik R, Chen CC, Kasper EM.

Neurocrit Care. 2021 Aug;35(1):87-102. doi: 10.1007/s12028-020-01143-7. Epub 2020 Nov 18.

PMID: 33205356

RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status.

Sinha A, Saleh A, Endersby R, Yuan SH, Chokshi CR, Brown KR, Kuzio B, Kauppinen T, Singh SK, Baker SJ, McKinnon PJ, Katyal S.

Cancers (Basel). 2020 Oct 29;12(11):3178. doi: 10.3390/cancers12113178.

PMID: 33138032 Free PMC article.

Survey of lumbar discectomy practices: 10 years in the making.

Aljoghaiman M, Martyniuk A, Farrokhyar F, Cenic A, Kachur E.

J Spine Surg. 2020 Sep;6(3):572-580. doi: 10.21037/jss-20-519.

PMID: 33102894 Free PMC article.

Assessment of Frailty in Predicting Surgical Outcomes in Patients with Chronic Subdural Hematomas: Retrospective Chart Review.

Kesserwan M, Bergin B, Trivedi A, Shakil H, Martyniuk A, Takroni R, Kasper E, Engels P, Farrokhyar F, Sharma S.

World Neurosurg. 2021 Feb;146:e168-e174. doi: 10.1016/j.wneu.2020.10.061. Epub 2020 Oct 17.

PMID: 33080405

Efficacy and safety of tranexamic acid in acute traumatic brain injury: a systematic review and meta-analysis of randomized-controlled trials.

Lawati KA, Sharif S, Maqbali SA, Rimawi HA, Petrosoniak A, Belley-Cote EP, Sharma SV, Morgenstern J, Fernando SM, Owen JJ, Zeller M, Quinlan D, Alhazzani W, Rochwerg B.

Intensive Care Med. 2021 Jan;47(1):14-27. doi: 10.1007/s00134-020-06279-w. Epub 2020 Oct 20.

PMID: 33079217

Mini-Tubular Access Surgery: A Single Surgeon's 12 Years in the Corridors of the Neuroaxis.

Zagzoog N, Alsunbul W, Elgheriani A, Takroni R, Reddy K.

J Neurol Surg A Cent Eur Neurosurg. 2020 Nov;81(6):513-520. doi: 10.1055/s-0039-1688561. Epub 2020 Sep 10.

PMID: 32911550

Genetics of Colloid Cyst in Monozygotic Twins: Case Report and Review of Literature.

Lannon M, Mackenzie J, Reddy K.

World Neurosurg. 2020 Dec;144:88-91. doi: 10.1016/j.wneu.2020.08.176. Epub 2020 Sep 2.

PMID: 32889197

Wnt activation as a therapeutic strategy in medulloblastoma.

Manoranjan B, Venugopal C, Bakhshinyan D, Adile AA, Richards L, Kameda-Smith MM, Whitley O, Dvorkin-Gheva A, Subapanditha M, Savage N, Tatari N, McKenna D, Bassey-Archibong B, Winegarden N, Hallett R, Provias JP, Yarascavitch B, Ajani O, Fleming A, Bader GD, Pugh TJ, Doble BW, Singh SK.

Nat Commun. 2020 Aug 28;11(1):4323. doi: 10.1038/s41467-020-17953-4.

PMID: 32859895 Free PMC article.

Immunohistochemical Markers in the Diagnosis of Calcifying Pseudoneoplasm of the Neuraxis.

Yang K, Reddy K, Wang BH, Cenic A, Provias J, Popovic S, Yong WH, Berthelet F, Bojanowski MW, Hammond R, Lu JQ.

Can J Neurol Sci. 2021 Mar;48(2):259-266. doi: 10.1017/cjn.2020.175. Epub 2020 Aug 17.

PMID: 32800010

Outcomes of civilian pediatric craniocerebral gunshot wounds: A systematic review.

Duda T, Sharma A, Ellenbogen Y, Martyniuk A, Kasper E, Engels PT, Sharma S.

J Trauma Acute Care Surg. 2020 Dec;89(6):1239-1247. doi: 10.1097/TA.0000000000002900.

PMID: 32756261

Collision Lesions of Calcifying Pseudoneoplasm of the Neuraxis and Rheumatoid Nodules: A Case Report With New Pathogenic Insights.

Lu JQ, Popovic S, Provias J, Cenic A.

Int J Surg Pathol. 2021 May;29(3):314-320. doi: 10.1177/1066896920941939. Epub 2020 Jul 15.

PMID: 32666850

Comparison of endoscopic third ventriculostomy with or without choroid plexus cauterization in pediatric hydrocephalus: a systematic review and meta-analysis.

Ellenbogen Y, Brar K, Yang K, Lee Y, Ajani O.

J Neurosurg Pediatr. 2020 Jul 3;26(4):371-378. doi: 10.3171/2020.4.PEDS19720.

PMID: 32619979 Review.

Modern Brain Retractors and Surgical Brain Injury: A Review.

Zagzoog N, Reddy KK.

World Neurosurg. 2020 Oct;142:93-103. doi: 10.1016/j.wneu.2020.06.153. Epub 2020 Jun 26.

PMID: 32599200 Review.

Myalgia and Hematuria in Association with Clonidine and Arginine Administration for Growth Hormone Stimulation Tests.

Glibbery M, Fleming A, Chanchlani R, Ajani OA, Marchetti N, Marr A, Samaan MC.

Case Rep Med. 2020 May 26;2020:4827072. doi: 10.1155/2020/4827072. eCollection 2020.

PMID: 32547619 Free PMC article.

The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma.

Vora P, Venugopal C, Salim SK, Tatari N, Bakhshinyan D, Singh M, Seyfrid M, Upreti D, Rentas S, Wong N, Williams R, Qazi MA, Chokshi C, Ding A, Subapanditha M, Savage N, Mahendram S, Ford E, Adile AA, McKenna D, McFarlane N, Huynh V, Wylie RG, Pan J, Bramson J, Hope K, Moffat J, Singh S.

Cell Stem Cell. 2020 Jun 4;26(6):832-844.e6. doi: 10.1016/j.stem.2020.04.008. Epub 2020 May 27.

PMID: 32464096

Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.

Michealraj KA, Kumar SA, Kim LJY, Cavalli FMG, Przelicki D, Wojcik JB, Delaidelli A, Bajic A, Saulnier O, MacLeod G, Vellanki RN, Vladoiu MC, Guilhamon P, Ong W, Lee JJY, Jiang Y, Holgado BL, Rasnitsyn A, Malik AA, Tsai R, Richman CM, Juraschka K, Haapasalo J, Wang EY, De Antonellis P, Suzuki H, Farooq H, Balin P, Kharas K, Van Ommeren R, Sirbu O, Rastan A, Krumholtz SL, Ly M, Ahmadi M, Deblois G, Srikanthan D, Luu B, Loukides J, Wu X, Garzia L, Ramaswamy V, Kanshin E, Sánchez-Osuna M, El-Hamamy I, Coutinho FJ, Prinos P, Singh S, Donovan LK, Daniels C, Schramek D, Tyers M, Weiss S, Stein LD, Lupien M, Wouters BG, Garcia BA, Arrowsmith CH, Sorensen PH, Angers S, Jabado N, Dirks PB, Mack SC, Agnihotri S, Rich JN, Taylor MD.

Cell. 2020 Jun 11;181(6):1329-1345.e24. doi: 10.1016/j.cell.2020.04.047. Epub 2020 May 22.

PMID: 32445698

Development of a peptide-based delivery platform for targeting malignant brain tumors.

Rahn JJ, Lun X, Jorch SK, Hao X, Venugopal C, Vora P, Ahn BY, Babes L, Alshehri MM, Cairncross JG, Singh SK, Kubes P, Senger DL, Robbins SM.

Biomaterials. 2020 Sep;252:120105. doi: 10.1016/j.biomaterials.2020.120105. Epub 2020 May 7.

PMID: 32417652

Neurosurgical management of conus lipoma in Canada: a multi-center survey.

Manoranjan B, Pozdnyakov A, Ajani O.

Childs Nerv Syst. 2020 Dec;36(12):3041-3045. doi: 10.1007/s00381-020-04641-3. Epub 2020 May 7.

PMID: 32382866

The Role of Anterior Cervical Discectomy and Fusion on Relieving Axial Neck Pain in Patients With Single-Level Disease: A Systematic Review and Meta-Analysis.

Oitment C, Watson T, Lam V, Aref M, Koziarz A, Kachur E, Badhiwala JH, Almenawer SA, Cenic A.

Global Spine J. 2020 May;10(3):312-323. doi: 10.1177/2192568219837923. Epub 2019 Mar 25.

PMID: 32313797 Free PMC article.

Visual Outcomes After Endoscopic Endonasal Resection of Orbital Lesions.

Yang K, Ellenbogen Y, Algird AR, Sommer DD, Reddy K.

World Neurosurg. 2020 Jul;139:e501-e507. doi: 10.1016/j.wneu.2020.04.050. Epub 2020 Apr 18.

PMID: 32311560

Incidental multifocal calcifying pseudoneoplasm of the neuraxis: case report and literature review.

Lu JQ, Yang K, Reddy KKV, Wang BH.

Br J Neurosurg. 2020 Mar 12:1-8. doi: 10.1080/02688697.2020.1738342. Online ahead of print.

PMID: 32162556

Salvage therapy for progressive, treatment-refractory or recurrent pediatric medulloblastoma: a systematic review protocol.

Adile AA, Kameda-Smith MM, Bakhshinyan D, Banfield L, Salim SK, Farrokhyar F, Fleming AJ.

Syst Rev. 2020 Mar 4;9(1):47. doi: 10.1186/s13643-020-01307-8.

PMID: 32127049 Free PMC article.

Pediatric medulloblastoma in the molecular era: what are the surgical implications?

Kameda-Smith MM.

Cancer Metastasis Rev. 2020 Mar;39(1):235-243. doi: 10.1007/s10555-020-09865-y.

PMID: 32095940 Review.

Radiation Necrosis Following Stereotactic Radiosurgery for Trigeminal Neuralgia.

Wang AP, Suryavanshi T, Marcucci M, Fong C, Whitton AC, Reddy KKV.

Can J Neurol Sci. 2020 May;47(3):425-427. doi: 10.1017/cjn.2020.24.

PMID: 32036796 No abstract available.

Skull Base Calcifying Pseudoneoplasms of the Neuraxis: Two Case Reports and a Systematic Review of the Literature.

Yang K, Reddy K, Ellenbogen Y, Wang BH, Bojanowski MW, Lu JQ.

Can J Neurol Sci. 2020 May;47(3):389-397. doi: 10.1017/cjn.2019.339.

PMID: 31843039

The expanded endoscopic endonasal approach for suprasellar meningiomas: long-term outcomes in a single-center series of 27 patients.

Yang K, Ellenbogen Y, Dong S, Kim J, Larrazabal R, Rodriguez AR, Algird AR, Sommer DD, Reddy K.

Acta Neurochir (Wien). 2020 Mar;162(3):623-629. doi: 10.1007/s00701-019-04113-x. Epub 2019 Dec 14.

PMID: 31836932

A CD133-AKT-Wnt signaling axis drives glioblastoma brain tumor-initiating cells.

Manoranjan B, Chokshi C, Venugopal C, Subapanditha M, Savage N, Tatari N, Provias JP, Murty NK, Moffat J, Doble BW, Singh SK.

Oncogene. 2020 Feb;39(7):1590-1599. doi: 10.1038/s41388-019-1086-x. Epub 2019 Nov 6.

PMID: 31695152

Spontaneous spinal CSF-venous fistulas associated with venous/venolymphatic vascular malformations: report of 3 cases.

Schievink WI, Maya MM, Moser FG, Tuchman A, Cruz RB, Farb RI, Rebello R, Reddy K, Prasad RS.

J Neurosurg Spine. 2019 Nov 1;32(2):305-310. doi: 10.3171/2019.8.SPINE19716.

PMID: 31675703

Hypertrophic Interstitial Neuropathy of the Trigeminal Nerve: Case Report and Literature Review.

Wang AP, Catana D, Provias JP, Reddy KKV.

Neurosurgery. 2020 Jul 1;87(1):E41-E47. doi: 10.1093/neuros/nyz418.

PMID: 31620786 Review.

Analysis of factors that influence neurosurgical length of hospital stay among newly diagnosed pediatric brain tumor patients.

Hasan M, Diep D, Manoranjan B, Maharaj A, Chaudhry S, Shaheen S, Farrokhyar F, Fleming AJ, Ajani O, Singh SK, Yarascavitch B.

Pediatr Blood Cancer. 2020 Jan;67(1):e28041. doi: 10.1002/pbc.28041. Epub 2019 Oct 14.

PMID: 31612572

Deciphering brain tumor heterogeneity, one cell at a time.

Qazi MA, Bakhshinyan D, Singh SK.

Nat Med. 2019 Oct;25(10):1474-1476. doi: 10.1038/s41591-019-0605-1.

PMID: 31541226 No abstract available.

Predictive measures and outcomes of extent of resection in juvenile pilocytic astrocytoma.

Maharaj A, Manoranjan B, Verhey LH, Fleming AJ, Farrokhyar F, Almenawer S, Singh SK, Yarascavitch B.

J Clin Neurosci. 2019 Dec;70:79-84. doi: 10.1016/j.jocn.2019.08.066. Epub 2019 Aug 26.

PMID: 31466905

Opioid-Free Analgesia for Supratentorial Craniotomies: A Systematic Review.

Darmawikarta D, Sourour M, Couban R, Kamath S, Reddy KK, Shanthanna H.

Can J Neurol Sci. 2019 Jul;46(4):415-422. doi: 10.1017/cjn.2019.57.

PMID: 31293233

Salvage Therapy for Childhood Medulloblastoma: A Single Center Experience.

Kameda-Smith MM, Wang A, Abdulhadi N, Voth R, Sergeant A, Maharaj A, Bakhshinyan D, Adile AA, Pai AM, Ajani O, Yarascavitch B, Alyman MC, Duckworth J, Samaan MC, Farrokhyar F, Singh SK, Fleming A; Pediatric Brain Tumour Study Group.

Can J Neurol Sci. 2019 Jul;46(4):403-414. doi: 10.1017/cjn.2019.39.

PMID: 31293232

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.

Sin-Chan P, Mumal I, Suwal T, Ho B, Fan X, Singh I, Du Y, Lu M, Patel N, Torchia J, Popovski D, Fouladi M, Guilhamon P, Hansford JR, Leary S, Hoffman LM, Mulcahy Levy JM, Lassaletta A, Solano-Paez P, Rivas E, Reddy A, Gillespie GY, Gupta N, Van Meter TE, Nakamura H, Wong TT, Ra YS, Kim SK, Massimi L, Grundy RG, Fangusaro J, Johnston D, Chan J, Lafay-Cousin L, Hwang EI, Wang Y, Catchpoole D, Michaud J, Ellezam B, Ramanujachar R, Lindsay H, Taylor MD, Hawkins CE, Bouffet E, Jabado N, Singh SK, Kleinman CL, Barsyte-Lovejoy D, Li XN, Dirks PB, Lin CY, Mack SC, Rich JN, Huang A.

Cancer Cell. 2019 Jul 8;36(1):51-67.e7. doi: 10.1016/j.ccell.2019.06.002.

PMID: 31287992

Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells.

Vora P, Seyfrid M, Venugopal C, Qazi MA, Salim S, Isserlin R, Subapanditha M, O'Farrell E, Mahendram S, Singh M, Bakhshinyan D, Chokshi C, McFarlane N, Dvorkin-Gheva A, Brown KR, Murty N, Moffat J, Bader GD, Singh SK.

J Neurooncol. 2019 Jul;143(3):417-428. doi: 10.1007/s11060-019-03192-1. Epub 2019 May 21.

PMID: 31115870

Letter: Familial Syndromes Involving Meningiomas Provide Mechanistic Insight Into Sporadic Disease.

Lu JQ, Reddy K.

Neurosurgery. 2019 Aug 1;85(2):E396. doi: 10.1093/neuros/nyz135.

PMID: 31058976 No abstract available.

Use of Minimally Invasive Tubular Retractors for Foramen Magnum Decompression of Chiari Malformation: A Technical Note and Case Series.

Zagzoog N, Reddy KK.

World Neurosurg. 2019 Aug;128:248-253. doi: 10.1016/j.wneu.2019.04.094. Epub 2019 Apr 29.

PMID: 31048052

Childhood cerebellar tumours mirror conserved fetal transcriptional programs.

Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD.

Nature. 2019 Aug;572(7767):67-73. doi: 10.1038/s41586-019-1158-7. Epub 2019 May 1.

PMID: 31043743 Free PMC article.

Dabigatran reversal by idarucizumab in the setting of intracranial hemorrhage: A systematic review of the literature.

Lu VM, Phan K, Rao PJ, Sharma SV, Kasper EM.

Clin Neurol Neurosurg. 2019 Jun;181:76-81. doi: 10.1016/j.clineuro.2019.04.013. Epub 2019 Apr 15.

PMID: 31015061

Mobile Applications in Neurosurgery: A Systematic Review, Quality Audit, and Survey of Canadian Neurosurgery Residents.

Bergeron D, Iorio-Morin C, Bigder M, Dakson A, Eagles ME, Elliott CA, Honey CM, Kameda-Smith MM, Persad ARL, Touchette CJ, Tso MK, Fortin D; Canadian Neurosurgery Research Collaborative.

World Neurosurg. 2019 Jul;127:e1026-e1038. doi: 10.1016/j.wneu.2019.04.035. Epub 2019 Apr 10.

PMID: 30980978

Regulation of the proline regulatory axis and autophagy modulates stemness in TP73/p73 deficient cancer stem-like cells.

Sharif T, Martell E, Dai C, Singh SK, Gujar S.

Autophagy. 2019 May;15(5):934-936. doi: 10.1080/15548627.2019.1586321. Epub 2019 Mar 8.

PMID: 30849274 Free PMC article.

A Review of Recent Advances in Endovascular Therapy for Intracranial Aneurysms.

Pai AM, Kameda-Smith M, van Adel B.

Crit Rev Biomed Eng. 2018;46(4):369-397. doi: 10.1615/CritRevBiomedEng.2018027003.

PMID: 30806250 Review.

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer.

Shouksmith AE, Shah F, Grimard ML, Gawel JM, Raouf YS, Geletu M, Berger-Becvar A, de Araujo ED, Luchman HA, Heaton WL, Bakhshinyan D, Adile AA, Venugopal C, O'Hare T, Deininger MW, Singh SK, Konieczny SF, Weiss S, Fishel ML, Gunning PT.

J Med Chem. 2019 Mar 14;62(5):2651-2665. doi: 10.1021/acs.jmedchem.8b01957. Epub 2019 Mar 6.

PMID: 30776234 Free PMC article.

A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations.

Nixon AML, Duque A, Yelle N, McLaughlin M, Davoudi S, Pedley NM, Haynes J, Brown KR, Pan J, Hart T, Gilbert PM, Singh SK, O'Brien CA, Sidhu SS, Moffat J.

Sci Rep. 2019 Jan 29;9(1):842. doi: 10.1038/s41598-018-37462-1.

PMID: 30696911 Free PMC article.

TAp73 Modifies Metabolism and Positively Regulates Growth of Cancer Stem-Like Cells in a Redox-Sensitive Manner.

Sharif T, Dai C, Martell E, Ghassemi-Rad MS, Hanes MR, Murphy PJ, Kennedy BE, Venugopal C, Subapanditha M, Giacomantonio CA, Marcato P, Singh SK, Gujar S.

Clin Cancer Res. 2019 Mar 15;25(6):2001-2017. doi: 10.1158/1078-0432.CCR-17-3177. Epub 2018 Dec 28.

PMID: 30593514

Endoscopic versus open microvascular decompression for trigeminal neuralgia: a systematic review and comparative meta-analysis.

Zagzoog N, Attar A, Takroni R, Alotaibi MB, Reddy K.

J Neurosurg. 2018 Dec 7:1-9. doi: 10.3171/2018.6.JNS172690. Online ahead of print.

PMID: 30544341 Review.

Unusual features of ependymoma in a patient with Parkinson's disease.

Witton LA, Fong C, Reddy K, Provias J, Lu JQ.

J Clin Neurosci. 2019 Jan;59:310-312. doi: 10.1016/j.jocn.2018.10.124. Epub 2018 Nov 6.

PMID: 30409527

Trigeminocardiac Reflex: Case Report and Literature Review of Intraoperative Asystole in Response to Manipulation of the Temporalis Muscle.

Shakil H, Wang AP, Horth DA, Nair SS, Reddy KKV.

World Neurosurg. 2019 Feb;122:424-427. doi: 10.1016/j.wneu.2018.10.186. Epub 2018 Nov 3.

PMID: 30399470 Review.

Discrepancies Between Patient and Surgeon Expectations of Surgery for Sciatica: A Challenge for Informed Decision Making?

Rehman Y, Syed M, Wiercioch W, Rehman N, Drew B, Cenic A, Reddy K, Murty N, Kucher E, Dunlop B, Guyatt GH, Busse JW, Schwartz L, Vanstone M.

Spine (Phila Pa 1976). 2019 May 15;44(10):740-746. doi: 10.1097/BRS.0000000000002914.

PMID: 30395083

BMI1 is a therapeutic target in recurrent medulloblastoma.

Bakhshinyan D, Venugopal C, Adile AA, Garg N, Manoranjan B, Hallett R, Wang X, Mahendram S, Vora P, Vijayakumar T, Subapanditha M, Singh M, Kameda-Smith MM, Qazi M, McFarlane N, Mann A, Ajani OA, Yarascavitch B, Ramaswamy V, Farooq H, Morrissy S, Cao L, Sydorenko N, Baiazitov R, Du W, Sheedy J, Weetall M, Moon YC, Lee CS, Kwiecien JM, Delaney KH, Doble B, Cho YJ, Mitra S, Kaplan D, Taylor MD, Davis TW, Singh SK.

Oncogene. 2019 Mar;38(10):1702-1716. doi: 10.1038/s41388-018-0549-9. Epub 2018 Oct 22.

PMID: 30348991

Postoperative Continuous Positive Airway Pressure Use and Nasal Saline Rinses After Endonasal Endoscopic Skull Base Surgery in Patients With Obstructive Sleep Apnea: A Practice Pattern Survey.

Choi DL, Reddy K, Weitzel EK, Rotenberg BW, Vescan A, Algird A, Sommer DD.

Am J Rhinol Allergy. 2019 Jan;33(1):51-55. doi: 10.1177/1945892418804987. Epub 2018 Oct 22.

PMID: 30345806

In Vivo Murine Models of Brain Metastasis.

Singh M, Savage N, Singh SK.

Methods Mol Biol. 2019;1869:231-238. doi: 10.1007/978-1-4939-8805-1_19.

PMID: 30324527

EPH Profiling of BTIC Populations in Glioblastoma Multiforme Using CyTOF.

Hu AX, Adams JJ, Vora P, Qazi M, Singh SK, Moffat J, Sidhu SS.

Methods Mol Biol. 2019;1869:155-168. doi: 10.1007/978-1-4939-8805-1_14.

PMID: 30324522

Differentiation of Brain Tumor Initiating Cells.

Kameda-Smith MM, Subapanditha MK, Salim SK, Venugopal C, Singh SK.

Methods Mol Biol. 2019;1869:85-91. doi: 10.1007/978-1-4939-8805-1_8.

PMID: 30324516

In Vitro Self-Renewal Assays for Brain Tumor Stem Cells.

Seyfrid M, Bobrowski D, Bakhshinyan D, Tatari N, Venugopal C, Singh SK.

Methods Mol Biol. 2019;1869:79-84. doi: 10.1007/978-1-4939-8805-1_7.

PMID: 30324515

Flow Cytometric Analysis of Brain Tumor Stem Cells.

Subapanditha MK, Adile AA, Venugopal C, Singh SK.

Methods Mol Biol. 2019;1869:69-77. doi: 10.1007/978-1-4939-8805-1_6.

PMID: 30324514

Detecting Stem Cell Marker Expression Using the NanoString nCounter System.

Ryall S, Arnoldo A, Sheth J, Singh SK, Hawkins C.

Methods Mol Biol. 2019;1869:57-67. doi: 10.1007/978-1-4939-8805-1_5.

PMID: 30324513

Introduction to Brain Tumor Stem Cells.

Yelle N, Bakhshinyan D, Venugopal C, Singh SK.

Methods Mol Biol. 2019;1869:1-9. doi: 10.1007/978-1-4939-8805-1_1.

PMID: 30324509 Review.

Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells.

Sharif T, Martell E, Dai C, Ghassemi-Rad MS, Lee K, Singh SK, Weaver ICG, Gujar S.

Cell Death Dis. 2018 Sep 24;9(10):990. doi: 10.1038/s41419-018-0997-8.

PMID: 30250195 Free PMC article.

Biopsy Versus Subtotal Versus Gross Total Resection in Patients with Low-Grade Glioma: A Systematic Review and Meta-Analysis.

Yang K, Nath S, Koziarz A, Badhiwala JH, Ghayur H, Sourour M, Catana D, Nassiri F, Alotaibi MB, Kameda-Smith M, Manoranjan B, Aref MH, Mansouri A, Singh S, Almenawer SA.

World Neurosurg. 2018 Dec;120:e762-e775. doi: 10.1016/j.wneu.2018.08.163. Epub 2018 Aug 30.

PMID: 30172972

Therapeutic Targeting of the Premetastatic Stage in Human Lung-to-Brain Metastasis.

Singh M, Venugopal C, Tokar T, McFarlane N, Subapanditha MK, Qazi M, Bakhshinyan D, Vora P, Murty NK, Jurisica I, Singh SK.

Cancer Res. 2018 Sep 1;78(17):5124-5134. doi: 10.1158/0008-5472.CAN-18-1022. Epub 2018 Jul 9.

PMID: 29986997

Spinal Dural Repair: A Canadian Questionnaire.

Oitment C, Aref M, Almenawar S, Reddy K.

Global Spine J. 2018 Jun;8(4):359-364. doi: 10.1177/2192568217724132. Epub 2017 Nov 8.

PMID: 29977720 Free PMC article.

A Canadian perspective on anterior cervical discectomies: practice patterns and preferences.

Baweja RK, Bennardo M, Farrokhyar F, Martyniuk A, Reddy K.

J Spine Surg. 2018 Mar;4(1):72-78. doi: 10.21037/jss.2018.03.01.

PMID: 29732425 Free PMC article.

Hypophysitis Due to Paranasal Sinusitis: Neurosurgical Perspective from Developing World.

El Malik EFB, Manoranjan B, Ajani O, Zidan A.

World Neurosurg. 2018 Jul;115:162-165. doi: 10.1016/j.wneu.2018.04.068. Epub 2018 Apr 17.

PMID: 29678705

Association of Glioblastoma Multiforme Stem Cell Characteristics, Differentiation, and Microglia Marker Genes with Patient Survival.

Bien-Möller S, Balz E, Herzog S, Plantera L, Vogelgesang S, Weitmann K, Seifert C, Fink MA, Marx S, Bialke A, Venugopal C, Singh SK, Hoffmann W, Rauch BH, Schroeder HWS.

Stem Cells Int. 2018 Jan 17;2018:9628289. doi: 10.1155/2018/9628289. eCollection 2018.

PMID: 29535786 Free PMC article.

The use of ibuprofen and acetaminophen for acute headache in the postconcussive youth: A pilot study.

Petrelli T, Farrokhyar F, McGrath P, Sulowski C, Sobhi G, DeMatteo C, Giglia L, Singh SK.

Paediatr Child Health. 2017 Mar;22(1):2-6. doi: 10.1093/pch/pxw011. Epub 2017 Mar 27.

PMID: 29483787 Free PMC article.

Multiple lobar intracerebral hemorrhage and cerebral amyloid angiopathy in the setting of ApoE Є2: a case report of the disease course and call for improved treatment modalities.

Thornley P, Oreskovich S, Provias J, Silva J, Reddy K, Cenic A.

J Surg Case Rep. 2017 Oct 20;2017(10):rjx208. doi: 10.1093/jscr/rjx208. eCollection 2017 Oct.

PMID: 29423148 Free PMC article.

Smartphone Usage Patterns by Canadian Neurosurgery Residents: A National Cross-Sectional Survey.

Kameda-Smith MM, Iorio-Morin C, Winkler-Schwartz A, Ahmed US, Bergeron D, Bigder M, Dakson A, Elliott CA, Guha D, Lavergne P, Makarenko S, Taccone MS, Tso M, Wang B, Fortin D; Canadian Neurosurgery Research Collaborative (CNRC).

World Neurosurg. 2018 Mar;111:e465-e470. doi: 10.1016/j.wneu.2017.12.089. Epub 2017 Dec 23.

PMID: 29277596

A 72-Year-Old Male with A Slow Growing Pineal Region Tumor.

Kameda-Smith MM, Lach B, Reddy KS.

Brain Pathol. 2018 Jan;28(1):129-130. doi: 10.1111/bpa.12578.

PMID: 29265634 Free PMC article. No abstract available.

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.

Mack SC, Pajtler KW, Chavez L, Okonechnikov K, Bertrand KC, Wang X, Erkek S, Federation A, Song A, Lee C, Wang X, McDonald L, Morrow JJ, Saiakhova A, Sin-Chan P, Wu Q, Michaelraj KA, Miller TE, Hubert CG, Ryzhova M, Garzia L, Donovan L, Dombrowski S, Factor DC, Luu B, Valentim CLL, Gimple RC, Morton A, Kim L, Prager BC, Lee JJY, Wu X, Zuccaro J, Thompson Y, Holgado BL, Reimand J, Ke SQ, Tropper A, Lai S, Vijayarajah S, Doan S, Mahadev V, Miñan AF, Gröbner SN, Lienhard M, Zapatka M, Huang Z, Aldape KD, Carcaboso AM, Houghton PJ, Keir ST, Milde T, Witt H, Li Y, Li CJ, Bian XW, Jones DTW, Scott I, Singh SK, Huang A, Dirks PB, Bouffet E, Bradner JE, Ramaswamy V, Jabado N, Rutka JT, Northcott PA, Lupien M, Lichter P, Korshunov A, Scacheri PC, Pfister SM, Kool M, Taylor MD, Rich JN.

Nature. 2018 Jan 4;553(7686):101-105. doi: 10.1038/nature25169. Epub 2017 Dec 20.

PMID: 29258295 Free PMC article.

Demographics, Interests, and Quality of Life of Canadian Neurosurgery Residents.

Iorio-Morin C, Ahmed SU, Bigder M, Dakson A, Elliott C, Guha D, Kameda-Smith M, Lavergne P, Makarenko S, Taccone MS, Tso MK, Wang B, Winkler-Schwartz A, Fortin D; Canadian Neurosurgery Research Collaborative.

Can J Neurol Sci. 2018 Mar;45(2):214-220. doi: 10.1017/cjn.2017.263. Epub 2017 Dec 14.

PMID: 29239294

Atraumatic versus conventional lumbar puncture needles: a systematic review and meta-analysis.

Nath S, Koziarz A, Badhiwala JH, Alhazzani W, Jaeschke R, Sharma S, Banfield L, Shoamanesh A, Singh S, Nassiri F, Oczkowski W, Belley-Côté E, Truant R, Reddy K, Meade MO, Farrokhyar F, Bala MM, Alshamsi F, Krag M, Etxeandia-Ikobaltzeta I, Kunz R, Nishida O, Matouk C, Selim M, Rhodes A, Hawryluk G, Almenawer SA.

Lancet. 2018 Mar 24;391(10126):1197-1204. doi: 10.1016/S0140-6736(17)32451-0. Epub 2017 Dec 7.

PMID: 29223694 Review.

Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma.

Badodi S, Dubuc A, Zhang X, Rosser G, Da Cunha Jaeger M, Kameda-Smith MM, Morrissy AS, Guilhamon P, Suetterlin P, Li XN, Guglielmi L, Merve A, Farooq H, Lupien M, Singh SK, Basson MA, Taylor MD, Marino S.

Cell Rep. 2017 Dec 5;21(10):2772-2784. doi: 10.1016/j.celrep.2017.11.021.

PMID: 29212025 Free PMC article.

Introduction to Cancer Stem Cells: Past, Present, and Future.

Bakhshinyan D, Adile AA, Qazi MA, Singh M, Kameda-Smith MM, Yelle N, Chokshi C, Venugopal C, Singh SK.

Methods Mol Biol. 2018;1692:1-16. doi: 10.1007/978-1-4939-7401-6_1.

PMID: 28986882 Review.

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